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Free NAPLEX Practice Questions

10 free, exam-style North American Pharmacist Licensure Examination (NAPLEX) (NAPLEX) practice questions with answers and explanations. No signup required. Work through them below, then take the full free NAPLEX practice test to study every exam domain.

Question 1

A 60-year-old female weighing 70 kg has a serum creatinine of 1.4 mg/dL. Using the Cockcroft-Gault equation, what is her estimated creatinine clearance (rounded to the nearest whole number)?

  1. 56 mL/min, omitting the 0.85 multiplier used for female patients
  2. 47 mL/min
  3. 62 mL/min, using actual body weight without any sex adjustment
  4. 39 mL/min
Show answer & explanation

Correct answer: B - 47 mL/min

Question 2

Using alligation, how many grams of 10% zinc oxide ointment must be combined with 1% zinc oxide ointment to prepare 120 g of a 2.5% zinc oxide ointment?

  1. 20 g of the 10% ointment
  2. 40 g of the 10% ointment
  3. 30 g of the 10% ointment
  4. 15 g of the 10% ointment
Show answer & explanation

Correct answer: A - 20 g of the 10% ointment

Question 3

A heparin infusion is ordered at 18 units/kg/hr for an 80 kg patient. The bag is labeled heparin 25,000 units in 250 mL of D5W. At what rate should the infusion pump be set (rounded to the nearest whole number)?

  1. 20 mL/hr, calculating the dose at 25 units/kg/hr
  2. 29 mL/hr, reading the bag as 25,000 units in 500 mL
  3. 14 mL/hr
  4. 36 mL/hr, doubling the hourly dose as a bolus
Show answer & explanation

Correct answer: C - 14 mL/hr

Question 4

Before initiating abacavir, a pharmacist recommends screening for a specific genetic marker to reduce the risk of a potentially fatal hypersensitivity reaction. Which marker should be tested?

  1. CYP2C19 loss-of-function allele
  2. TPMT deficiency
  3. VKORC1 variant
  4. HLA-B*57:01
Show answer & explanation

Correct answer: D - HLA-B*57:01

Question 5

In a clinical trial, the rate of stroke over one year was 15% in the placebo group and 10% in the treatment group. What is the number needed to treat (NNT) to prevent one additional stroke?

  1. 10, taken as the inverse of the treatment event rate
  2. 20
  3. 7, taken as the inverse of the control event rate
  4. 3, taken as the inverse of the relative risk reduction
Show answer & explanation

Correct answer: B - 20

Question 6

A 34-year-old recreational runner is treated for a urinary tract infection. The pharmacist counsels him about a boxed warning for tendinitis and tendon rupture associated with his antibiotic. Which medication was most likely prescribed?

  1. Nitrofurantoin
  2. Trimethoprim-sulfamethoxazole
  3. Amoxicillin
  4. Ciprofloxacin
Show answer & explanation

Correct answer: D - Ciprofloxacin

Question 7

A 28-year-old woman who is 12 weeks pregnant comes to the pharmacy during influenza season and asks which of her due vaccines must be deferred until after she delivers. Which vaccine is contraindicated during pregnancy?

  1. Inactivated influenza vaccine (IIV)
  2. Tetanus, diphtheria, and acellular pertussis (Tdap)
  3. Measles, mumps, and rubella (MMR), a live attenuated vaccine
  4. Hepatitis B vaccine
Show answer & explanation

Correct answer: C - Measles, mumps, and rubella (MMR), a live attenuated vaccine

Question 8

A nurse calls because a patient with a feeding tube cannot swallow tablets and asks which of the patient's medications may be crushed and given through the tube. Which product must NOT be crushed?

  1. Metoprolol succinate extended-release
  2. Lisinopril immediate-release tablet
  3. Metformin immediate-release tablet
  4. Prednisone immediate-release tablet
Show answer & explanation

Correct answer: A - Metoprolol succinate extended-release

Question 9

A patient brings in a partially used bottle of immediate-release oxycodone and asks how to safely dispose of it at home when no drug take-back program is available. Based on current FDA guidance, what is the most appropriate recommendation?

  1. Mix the tablets with used coffee grounds in a sealed bag and place them in the household trash
  2. Flush the remaining tablets down the toilet
  3. Keep the leftover medication on hand in case the pain returns later
  4. Empty the tablets into the kitchen drain and rinse them down with hot water
Show answer & explanation

Correct answer: B - Flush the remaining tablets down the toilet

Question 10

A 68-year-old man with heart failure with reduced ejection fraction (EF 30%) and atrial fibrillation needs improved rate control. Which medication should be AVOIDED because its negative inotropic effect can worsen his heart failure?

  1. Amlodipine
  2. Metoprolol succinate
  3. Diltiazem
  4. Digoxin
Show answer & explanation

Correct answer: C - Diltiazem

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